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François Moreau-Gaudry Selected Research

Erythropoietic Porphyria (Congenital Erythropoietic Porphyria)

11/2020Iron chelation rescues hemolytic anemia and skin photosensitivity in congenital erythropoietic porphyria.
1/2020Mutation-Specific Guide RNA for Compound Heterozygous Porphyria On-target Scarless Correction by CRISPR/Cas9 in Stem Cells.
12/2019Genetic background influences hepcidin response to iron imbalance in a mouse model of hemolytic anemia (Congenital erythropoietic porphyria).
1/2019CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations.
7/2012Metabolic correction of congenital erythropoietic porphyria with iPSCs free of reprogramming factors.
8/2010Modeling of congenital erythropoietic porphyria by RNA interference: a new tool for preclinical gene therapy evaluation.
6/2008Erythropoietic porphyrias: animal models and update in gene-based therapies.
6/2008[Successful gene therapy of mice with congenital erythropoietic porphyria].
1/2008Effective gene therapy of mice with congenital erythropoietic porphyria is facilitated by a survival advantage of corrected erythroid cells.

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François Moreau-Gaudry Research Topics

Disease

11Neoplasms (Cancer)
10/2021 - 10/2007
9Erythropoietic Porphyria (Congenital Erythropoietic Porphyria)
11/2020 - 01/2008
3Hemolytic Anemia
11/2020 - 07/2012
3Porphyrias (Porphyria)
01/2020 - 06/2008
3Pancreatic Neoplasms (Pancreatic Cancer)
10/2019 - 10/2012
3Adenocarcinoma
01/2019 - 10/2012
3Erythropoietic Protoporphyria
04/2014 - 09/2003
3BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
01/2013 - 03/2003
2Iron Overload
11/2020 - 12/2019
2Hemolysis
11/2020 - 12/2019
2Anemia
11/2020 - 12/2019
2Neoplasm Metastasis (Metastasis)
01/2020 - 01/2017
2Primary hyperoxaluria type 1
10/2019 - 01/2019
2Liver Failure
07/2011 - 06/2008
1Muscular Dystrophies (Muscular Dystrophy)
10/2021
1Obesity
01/2021
1Circulating Neoplastic Cells
04/2020
1Congenital Hemolytic Anemia (Hemolytic Anemia, Congenital)
12/2019
1Renal Insufficiency (Renal Failure)
10/2019
1Urolithiasis
10/2019
1Nephrocalcinosis
10/2019
1Chronic Kidney Failure (Chronic Renal Failure)
01/2019
1Teratoma (Teratoid Tumor)
01/2017
1Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral)
10/2016
1Liver Cirrhosis (Hepatic Cirrhosis)
07/2011
1Liver Diseases (Liver Disease)
07/2011
1Liver Neoplasms (Liver Cancer)
08/2009
1Hepatocellular Carcinoma (Hepatoma)
10/2007
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
04/2007
1Infections
01/2007
1Leukemia
03/2003
1Paroxysmal Hemoglobinuria (Paroxysmal Nocturnal Hemoglobinuria)
03/2003
1Hepatitis
01/2003

Drug/Important Bio-Agent (IBA)

7Heme (Haem)IBA
11/2020 - 09/2003
7EnzymesIBA
10/2019 - 09/2003
5Uroporphyrinogen III Synthetase (Uroporphyrinogen-III Synthase)IBA
11/2020 - 01/2008
4PorphyrinsIBA
11/2020 - 06/2008
3Biomarkers (Surrogate Marker)IBA
01/2020 - 10/2019
3Tyrosine Kinase InhibitorsIBA
07/2013 - 03/2003
2IronIBA
11/2020 - 12/2019
2DNA (Deoxyribonucleic Acid)IBA
01/2020 - 01/2019
2OxalatesIBA
10/2019 - 01/2019
2Alanine-glyoxylate transaminase (alanine-glyoxylate aminotransferase)IBA
10/2019 - 01/2019
2ResveratrolIBA
01/2019 - 01/2017
2Capsaicin (Zostrix)FDA Link
01/2019 - 01/2017
2Ferrochelatase (Heme Synthetase)IBA
04/2014 - 09/2003
2Proteins (Proteins, Gene)FDA Link
10/2012 - 03/2003
2protoporphyrin IXIBA
07/2011 - 09/2003
2Messenger RNA (mRNA)IBA
08/2009 - 10/2007
2Imatinib Mesylate (Gleevec)FDA Link
06/2007 - 03/2003
1Chimeric Antigen ReceptorsIBA
10/2021
1SodiumIBA
01/2021
1AlbuminsIBA
01/2021
1Ferritins (Ferritin)IBA
01/2021
1DeferiproneIBA
11/2020
1Biological ProductsIBA
04/2020
1Tumor Biomarkers (Tumor Markers)IBA
01/2020
1RNA (Ribonucleic Acid)IBA
01/2020
1HepcidinsIBA
12/2019
1Calcium OxalateIBA
01/2019
11,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA
01/2019
1Reactive Oxygen Species (Oxygen Radicals)IBA
01/2019
1SaltsIBA
01/2019
1CalciumIBA
01/2019
1Nucleoside-Diphosphate KinaseIBA
01/2017
1Protein Kinases (Protein Kinase)IBA
01/2017
1LuciferasesIBA
01/2017
1sulforaphaneIBA
01/2017
13,3',4,5'-tetrahydroxystilbeneIBA
01/2017
1SurvivinIBA
01/2017
1GemcitabineFDA Link
01/2017
1Dual-Specificity PhosphatasesIBA
10/2016
1Antisense OligonucleotidesIBA
04/2014
1Ganciclovir (Cytovene)FDA LinkGeneric
10/2012
1Surface Antigens (Surface Antigen)IBA
10/2012
1Mucin-4IBA
10/2012
1Busulfan (Busulfex)FDA Link
07/2011
1Cyclin D1IBA
08/2009
1Epidermal Growth Factor (EGF)IBA
08/2009
1Heparin (Liquaemin)FDA LinkGeneric
08/2009
1DNA HelicasesIBA
10/2007
1AgarIBA
10/2007
1Adenosine Triphosphatases (ATPase)IBA
10/2007
1Small Interfering RNA (siRNA)IBA
10/2007
1beta CateninIBA
10/2007
1CeramidesIBA
10/2007
1CytokinesIBA
06/2007
1nilotinibFDA Link
06/2007
1Proteasome InhibitorsIBA
04/2007
1Phosphoglycerate Kinase (Kinase, Phosphoglycerate)IBA
01/2007
1Alkylating AgentsIBA
01/2007
1Complementary DNA (cDNA)IBA
03/2003
1Membrane Proteins (Integral Membrane Proteins)IBA
03/2003
1ElementsIBA
01/2003

Therapy/Procedure

7Therapeutics
10/2021 - 06/2008
3Drug Therapy (Chemotherapy)
01/2019 - 04/2007
2Bone Marrow Transplantation (Transplantation, Bone Marrow)
07/2011 - 06/2008
1Endovascular Procedures
01/2019
1Radiotherapy
01/2019
1Liver Transplantation
06/2008